Nianyin Zeng, Yurong Li and Min Du

DOI: http://dx.doi.org/10.15379/2409-3394.2015.02.01.6

Published: 29 April 2015

The rapid immunochromatographic test strip, also called lateral flow immunoassay (LFIA), has recently attracted considerable research attention in the past decade because of its advantages when applied to a wide variety of point-of-care (POC) tests. This paper reviewed recent advances on modeling the LFIA and summarized their advantages and limitations. It is worth mentioning that there is a growing research interest on the general modeling issue for the LFIA system. In order to optimize LFIA performance for the purpose of quantification, it is of great importance to develop a mathematical model that allows us to simulate dynamic characteristics and also find out the effects of various design parameters in a both rapid and inexpensive way.

Lateral flow immunoassay, modeling, convection diffusion reaction, nonlinear state-space model, stochastic dynamic model, immunochromatographic assay.