Saturday, June 07, 2025

jht

G J H B T

Global Journal of Hematology and Blood Transfusion is committed to dissemination of high-quality research related to the latest trends and advances in the field of Hematology and Blood Transfusion.

Read More

fp-IJNMR

I J N M R

International Journal of Nuclear Medicine Research provides an authoritative setting for the publication of high quality internationally-relevant research with respect to the field of Nuclear Medicine. Nuclear Medicine is crucial to early diagnosis and treatment of diseases that threaten human lives.

fp-IJGONC

I J G O N C

International journal of Gynecology, Obstetrics and Neonatal Care is a peer reviewed medical journal provides up-to-date results of basic and clinical studies in Gynecology, Obstetrics and Neonatology. The primary mission of the journal is to promote improvement in the health.

fp-IJAAPR

I J A A P R

International Journal of Advanced Applied Physics Research is a refereed and highly professional journal that publishes premium theoretical and pragmatic papers in the field of Applied Physics.

fp-IJCLPR

I J C L R

International Journal of Cardiology and Lipidology Research is a peer reviewed medical journal which strengthen the research and educational base of Cardiology and Lipidology.We publish original research articles, reviews, case studies, conference papers and short notes related to aforementioned field.

neuro

J A N R

Journal of Advanced Neuroscience Research is a peer reviewed scientific journal providing fascinating and unique forum for publishing original experimental and review articles.

Read More

oncology

W J O R

World Journal of Oncology Research is a peer-reviewed scientific journal which strengthens the research and educational base of Oncology.

Read More

clinical

J C M R U

Journal of Clinical Medicine Research Updates is an international peer reviewed journal related to latest advances in all areas of clinical medicine.

Read More

food

I J F P T

International Journal of Food Processing Technology is a peer reviewed scientific journal providing an authoritative setting for the publication of internationally-relevant research.

Read More

proteomics

J T P R

Journal of Translational Proteomics Research is a scientific journal providing a scholarly forum for novel scientific research in the field of translational proteomics.

Read More

Latest News

Latest Issue of “ International Journal of Membrane Science and Technology” has published. Visit link; “ Latest Issue" ....! Special Issue of “International Journal of Membrane Science and Technology” is scheduled for Feb-2022..! Kindly Visit link: “Special Issues for IJMST”

Abstract: A Medical Emergency: “Leukostasis”

Global Journal of Hematology and Blood Transfusion (Volume 2 Issue 2)
A Medical Emergency: “Leukostasis”
Pages 25-32 B. Uz DOI: http://dx.doi.org/10.15379/2408-9877.2015.02.02.05 Published: 30 July 2015
Abstract
Hyperleukocytosis is commonly defined as a white blood cell (WBC) count exceeding 50-100 x 10⁹ L^-1 in peripheral blood and can be seen in newly diagnosed leukemias. Increased WBC count can lead to increased blood viscosity, leukocyte aggregation, and consequently stasis in blood vessels. Hyperleukocytic leukemia is associated with a risk of organ failure and early death secondary to leukostasis. The main sites that tend to be injured are the central nervous system (CNS) and lungs. The goal of the treatment of hyperleukocytosis and/or leukostasis is to remove leukocytes or blasts from the peripheral circulation as soon as possible and to prevent or reduce acute symptoms of leukostasis. The cytoreduction can generally be achieved by leukapheresis and/or some chemotherapeutic agents before starting induction chemotherapy. Leukapheresis is an effective and safe procedure which can be used for symptomatic relief, some special and rare conditions (serious respiratory failure, CNS involvement, priapism), or prophylactically. The supportive care has to be a part of the treatment in order to prevent tumor lysis syndrome or coagulopathy. The difference of hyperleukocytosis and leukostasis, pathophysiology and clinical presentation of leukostasis, and treatment options of hyperleukocytosis and/or leukostasis in the light of the current literature will be discussed in this review.
Keywords
Hyperleukocytosis, Leukostasis, Cytoreduction, Leukapheresis.

Indexed In

CROSSREF

2co

copyrc