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Global Journal of Hematology and Blood Transfusion is committed to dissemination of high-quality research related to the latest trends and advances in the field of Hematology and Blood Transfusion.

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International Journal of Nuclear Medicine Research provides an authoritative setting for the publication of high quality internationally-relevant research with respect to the field of Nuclear Medicine. Nuclear Medicine is crucial to early diagnosis and treatment of diseases that threaten human lives.

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International journal of Gynecology, Obstetrics and Neonatal Care is a peer reviewed medical journal provides up-to-date results of basic and clinical studies in Gynecology, Obstetrics and Neonatology. The primary mission of the journal is to promote improvement in the health.

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International Journal of Advanced Applied Physics Research is a refereed and highly professional journal that publishes premium theoretical and pragmatic papers in the field of Applied Physics.

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International Journal of Cardiology and Lipidology Research is a peer reviewed medical journal which strengthen the research and educational base of Cardiology and Lipidology.We publish original research articles, reviews, case studies, conference papers and short notes related to aforementioned field.

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Journal of Advanced Neuroscience Research is a peer reviewed scientific journal providing fascinating and unique forum for publishing original experimental and review articles.

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World Journal of Oncology Research is a peer-reviewed scientific journal which strengthens the research and educational base of Oncology.

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Journal of Clinical Medicine Research Updates is an international peer reviewed journal related to latest advances in all areas of clinical medicine.

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International Journal of Food Processing Technology is a peer reviewed scientific journal providing an authoritative setting for the publication of internationally-relevant research.

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Journal of Translational Proteomics Research is a scientific journal providing a scholarly forum for novel scientific research in the field of translational proteomics.

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Latest Issue of “ International Journal of Membrane Science and Technology” has published. Visit link; “ Latest Issue" ....! Special Issue of “International Journal of Membrane Science and Technology” is scheduled for Feb-2022..! Kindly Visit link: “Special Issues for IJMST”

Abstract: Expression of the Recombinant Soluble Glycoprotein IIb: Lessons Learned and Future Directions

Global Journal of Hematology and Blood Transfusion (Volume 2 Issue 2)
Expression of the Recombinant Soluble Glycoprotein IIb: Lessons Learned and Future Directions
Pages 16-19 Younis Skaik DOI: http://dx.doi.org/10.15379/2408-9877.2015.02.02.03 Published: 30 July 2015
Abstract
The platelet glycoprotein IIb (GPIIb) is an integral membrane protein, which forms with GPIIIa a calcium-dependent heterodimer. This heterodimer forms in the endoplasmic reticulum (RE) and in the absence of heterodimer formation, both GPIIb and GPIIIa are retained and degraded in the ER. Efforts have been previously made to produce recombinantly the soluble GPIIb, which can be used in the solid phase assays for the antibody identification. However, all previous attempts to produce such a construct have not yield any product. This mini-review describes the previous attempts and the future challenges.
Keywords
GPIIb, Soluble GPIIb, Recombinant GPIIb, Retention signal.

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