| Journal of Advanced Neuroscience Research (Volume 3 Issue 2) | |
| White and Grey Matter Abnormalities in Autism Align with Verbal Ability |  |
| Pages 24-31 Sabine V. Huemer, Frithjof Kruggel, Virginia Mann and J.G. Gehricke DOI: http://dx.doi.org/10.15379/2409-3564.2016.03.02.01Published: 28 October 2016 |
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| Abstract | |
| This whole-brain structural magnetic resonance imaging (MRI) investigation of autism spectrum disorder (ASD) analyzed white and grey matter concentrations, shape differences, and brain microstructure in 20 adolescents with ASD and 10 neurotypical controls. Evidence for significant group-related differences was found in nine regions, most associated with language processing, including the precentral gyrus, the anterior cingulate, the operculum, superior frontal, and superior temporal gyri. An additional analysis revealed that lower scores from a standardized measure of receptive verbal ability correlated with reduced white matter in the arcuate and uncinate fascicles, inthalamo-frontal and thalamo-cerebellar connections, and in interhemispheric connections passing through the callosal sections I and V. Our findings point to distinct neurological subgroups in ASD which align with the level of verbal ability. | |
| Keywords | |
| Autism spectrum disorder, Receptive verbal ability, Neurological subgroups, Adolescents, Structural magnetic resonance imaging | |
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