| Journal of Advanced Neuroscience Research (Volume 2 Issue 2) | |
| Restorative Effect of Distillated Nerium Oleander Extract on Diabetic Neuropathy: Animal Model Study |  |
| Pages 16-21 Sirma Basak Yanardag, Ahmet Akkoca, Figen Çiçek and Murat Ayaz DOI: http://dx.doi.org/10.15379/2409-3564.2015.02.02.3Published: 29 October 2015 |
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| Abstract | |
| The current study aims to investigate the possible role of Nerium oleander (NeOL) distillate in the treatment of diabetic neuropathy. The restorative affects of distillated NeOL on the diabetes-induced electrophysiological alterations were investigated. Induction of diabetes was done by the combination of single dose streptozotocin injection together with a high fat diet for four weeks. Experimental groups were designed as follows: control, diabetic, and NeOL treated diabetic. Nerve conduction velocity (CV) recordings were performed through a suction electrode from the tibia branch of the sciatic nerve trunk. Diabetes results an increase in rheobase, chronaxie values together with a decrease in maximum depolarization (MD), compound action potential (CAP) area and CV measurements. With its antioxidant nature, NeOL treatment produced nearly complete restorations of the diabetes-induced alterations. Current study has shown that distillated NeOL (375 µg /0.5 ml dH2O /day) can be a highly potential therapeutic agent on the diabetes induced alterations. | |
| Keywords | |
| Type II Diabetes, Neuropathy, Nerium oleander, Rat, Sciatic Nerve. | |
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