International Journal of Nuclear Medicine Research  (Volume 1 Issue 1)
 Cortico-Subcortical Metabolic Changes in Aging Brain: A 18F FDG PET/CT Study Nuclear
Pages 17-23

Agostino Chiaravalloti, Paolo Abbatiello, Ferdinando Calabria, Barbara Palumbo, Alessandro Martoranaand Orazio Schillaci

Published: 12 August 2014
 Aim: to investigate the effects of aging on brain glucose consumption on a population of healthy subjects.
 Materials and methods: 102 chemotherapy-naïve subjects (56 men, 46 women; mean age 57±16 years old; age range 20-89 years) undergoing a whole body 18F FDG PET/CT and found to be completely negative for various diseases in both PET/CT and contrast enhanced CT (performed contextually to PET/CT scan) were enrolled in the study. Age-related changes in brain 18F-FDG uptake were analysed by statistical parametric mapping (SPM8).
 Results: aging is related to a reduction of brain glucose consumption in right medial frontal gyrus (BA9) and anterior cingulate cortex (BA32) and to an increased 18F-FDG uptake in right sub-cortical structures (lentiform nucleus, claustrum) and in cerebellum bilaterally.
 Conclusions: The results of our study suggest that a reduced functioning of ACC and medial PFC occur in the elderly. An increased activation of the cerebellum, lentiform nucleus and claustrummay represent a compensatory mechanism, possibly involved in cognitive decline.
 Aging brain, Claustrum, Cingulate cortex, Prefrontal cortex, Cerebellum, PET/CT.