| International Journal of Cardiology and Lipidology Research (Volume 2 Issue 1) |
| Effects of Physical Activity on The Inflammatory Process Related to Insulin Resistance and Obesity |
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Pages 20-26
Aline Marcadenti, Francisca Mosele, Mirna Stela Ludwig, Thiago Gomes Heck and Erlon Oliveira de Abreu-Silva
DOI: http://dx.doi.org/10.15379/2410-2822.2015.02.01.05
Published: 21 March 2015 |
| Abstract |
| Atherosclerosis, the pathophysiological substrate for cardiovascular disease (CVD), is the final stage of an inflammatory cascade. During the process, endothelial dysfunction ensues and the inflammatory state is perpetuated. A number of traditional risk factors, as obesity and insulin resistance/type 2 diabetes, are characterized by a proinflammatory state as well, with increased levels of cytokines, interleukins, vasoactive peptides and enhanced expression of specific cellular receptors. The anti-inflammatory properties of physical exercise and its positive effects as a strategy for obesity and insulin resistance have already been shown in terms of cardiovascular protection and survival. |
| Keywords |
| Inflammation, Endothelial dysfunction, Obesity, Insulin resistance, Exercise. |
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