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introduction: Gabapentin is a second generation anticonvulsant that is effective in the treatment of chronic neuropathic pain. Recent data suggests its perioperative administration for attenuation of the hemodynamic response to laryngoscopy and intubation. The aim of this study was to compare Oral Gabapentin premedication with no premedication in patients undergoing rigid laryngoscopy and endotracheal intubation for General Anaesthesia in terms of mean heart rate and mean arterial pressure.
Methods:This was a randomized controlled trial conducted at Anesthesia Department Holy Family Hospital Rawalpindi. Total 100 patients were included in the study and randomly divided into 2 groups. In Group-A patients were given 800 mg Gabapentin orally and in Group-B patients were not given Gabapentin orally. Baseline parameters (including heart rate, Mean Arterial Pressure MAP) were recorded 1 hr. before surgery. Drug selected for given patient was given orally with a sip of water. After 1 hr. Data was collected on a standardized Performa and analyzed on SPSS 16 version.
Results:Mean hear rate in Group-A patients at 1st, 3rd, 5th and at 10th minute was 96.22±11.96, 91.84±11.28, 84.66±10.98 and 82.10±11.47 respectively. While in Group-B mean heart rate in Group-B patients at 1st, 3rd, 5th and at 10th minute was 105.70±11.95, 100.42±11.58, 92.18±10.56 and 88.40±9.61 respectively. It was observed that at 1st , 3rd , 5th and at 10th minute mean heart rate was statistically different in both treatment groups. Mean arterial pressure in Group-A patients at 1st, 3rd, 5th and at 10th minute was 103.68±6.55, 100.42±5.63, 96.54±5.72 and 95.04±5.86 respectively. While in Group-B mean arterial pressure in Group-B patients at 1st, 3rd, 5th and at 10th minute was 112.40±6.93, 106.60±5.98, 100.90±5.95 and 99.16±5.69 respectively. It was observed that at 1st, 3rd, 5th and at 10th minute mean arterial pressure was statistically different in both treatment groups.
Conclusion:800 mg oral gabapentin given 1 hour before undergoing rigid laryngoscopy and endotracheal intubation for general anesthesia significantly affects mean heart rate and mean arterial pressure at 1st, 3rd, 5th and at 10th minute.
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