World Journal of Oncology Research  (Volume 2)

Fereshteah Jafaei Nodeh, Seyedeh Maryam Sharafi, Sepideh Tuloee, Seyed Hossein Hejazi, Zahra Dorosti and Hossein Yousofi Darani

Introduction: Hydatid cyst is the larval stage of Echinococcusgranulosus, a parasite responsible for hydatid disease in human and livestock. The Effect of different antigens of this parasite in preventing the growth of tumor cells has been demonstrated in various studies. Therefore, in this work the effect of passive transfer of antisera raised against different antigens of Hydatid cyst on melanoma cancer growth in animal model has been investigated.
Methods: In this experimental study, antisera against different antigens of hydatid cyst raised in rabbits. C57/black mice were injected with melanoma cells and then they received anti hydatid cyst antigen antisera. Control mice received normal rabbit serum or saline. Tumor size in the case and control groups was measured. Then, the data were analyzed using SPSS software and one-way Anova test.
Findings: The mean tumor area in mice that received antisera against hydatidcyst fluid, protoscolices crude antigen, excretory-secretory antigens of protoscolices and cuticular layer was not significantly different from tumor area of control mice.
Conclusion: The results of this study showed that injection of antisera against antigens of hydatid cyst had no significant effect on melanoma tumor growth. So it is recommended that effect of transfer of immune cells is investigated in future studies.