| Global Journal of Hematology and Blood Transfusion (Volume 4 Issue 1) | |
| Management of Allogeneic Stem Cell Transplant Recipients with Hepatic Veno-Occlusive Disease |  |
| Pages 1-9 Alessandro Busca DOI: http://dx.doi.org/10.15379/2408-9877.2017.04.01.01Published: 30 January 2017 |
|
| Abstract | |
|
Hepatic veno-occlusive disease (VOD) or sinusoidal obstruction syndrome (SOS) is one the major limiting factor for the successful outcome of patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT), with a reported mortality rate of up to 50%. VOD/SOS is thought to result from an endothelial damage and occurs with a highly variable incidence ranging from 8% to 14%. Management of patients with VOD/SOS is based on both prevention and treatment, which rely on non-pharmacological approaches, for instance the control of additional risk factors, and pharmacologic treatments. Herein we provide a review of the current understanding for the management of patients with VOD/SOS after allogeneic HSCT. |
|
| Keywords | |
| Hepatic VOD/SOS, Endothelial damage, Transplant-related complications, Defibrotide. | |
 |
|