| Global Journal of Hematology and Blood Transfusion (Volume 2 Issue 1) |
| Ferrous sulfate versus ferrous fumarate plus zinc sulfate and vitamin C for treatment of iron deficiency anemia in children |
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Pages 15-19
Ali Aycicek
DOI: http://dx.doi.org/10.15379/2408-9877.2015.02.01.04
Published: 09 January 2015
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| Abstract |
| During childhood, different oral iron preparations are widely used in iron deficiency anemia (IDA) and prophylaxis. The purpose of this study was to compare the efficacy of different oral iron preparations in children with IDA. Eighty-nine children (age range, 1 to 17 years) with IDA were randomized to receive therapy orally in two divided doses of either 5 mg Fe2+/kg/day ferrous sulfate (FS group, n = 45) or ferrous fumarate plus zinc and vitamin C (FZ group, n = 44). Hematological profile and iron status were evaluated at the beginning and on days 15 and 45 of treatment. Mean Hb, mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), red cell distribution weight (RDW), and iron and ferritin levels were significantly higher in bothgroups on days 15 and 45 of treatment. Mean changes in Hb were 2.5 ± 1.2 g/dL and 2.1 ± 0.7 g/dL on day 15 (P = 0.295), and 3.9 ± 1.8 g/dL and 3.5 ± 1.2 g/dL on day 45 (P = 0.331) in the FS and FZ groups, respectively. Our study suggests that ferrous sulfate and ferrous fumarate plus zinc and vitamin C were well tolerated and were highly effective in correcting IDA in children. Ferrous fumarate plus zinc and vitamin C did not influence hematologic recovery compared with ferrous sulfate in this group. |
| Keywords |
| Anemia, iron deficiency, ferrous sulfate, ferrous fumarate, children, zinc, vitamin C. |
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