Abstract: Serum Concentration and Polymorphisms of Apolipoproteins A-I and B, and Risk of Coronary Artery Disease

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International Journal of Cardiology and Lipidology Research (Volume 2 Issue 1)
Serum Concentration and Polymorphisms of Apolipoproteins A-I and B, and Risk of Coronary Artery Disease
Pages 27-35 Johanny Aguillón, Nelsy Loango, Alejandra María Giraldo, Hugo Castaño and Patricia Landázuri DOI: http://dx.doi.org/10.15379/2410-2822.2015.02.01.06 Published: 14 April 2015
Abstract
Introduction: Variations in the apoprotein apoA-I and apoB genes have been associated with their serum concentration, and thus with Coronary Artery Disease (CAD). This study determined the relationship between polymorphism and the serum concentration of apoA-I and apoB in a group of patients with angiographically documented CAD. Materials and methods: Polymorphic sites, XbaI (in apoB), and MspI (in apo A-I) and serum concentrations in these lipoproteins were determined in a population of 231patients classified into two groups: patients with significant CAD (coronary obstruction ≥50%) and patients with mild CAD (coronary obstruction <50%); the apoB/apoA-I ratio was then calculated. Results: It was found that the M2 allele in the apoA-I acts as a risk factor for coronary artery disease, odds ratio=1.78(confidence interval: 1.21 – 2.61), p =0.002. Nosignificant differences were found between the apoA-I concentration values and the corresponding MspI polymorphism genotypes in the two study groups. Meanwhile, the apoB concentration presented significant differences among the XbaI (p=0.027) polymorphism genotypes, with greater values for the heterozygous genotype in patients with CAD≥50%. Likewise, a significantly abnormal difference was evident in the apoB/apoA-I ratio among the two groups, with a greater value for patients with mild CAD. Conclusion: the data showed that the M2allele may be a risk factor for CAD in this population. Additionally, it showed that there is a relationship between apoB serum concentration and XbaI polymorphism; relationship which manifests itself more strongly in patients with CAD. There was no relationship established between the MspI polymorphism of apoA-I and its serum concentration. Other studies are necessary in order to establish the anomalous behavior of the apoB/apoA-I relation in this population.
Keywords
Apolipoprotein, Polymorphism, Coronary artery disease (CAD), ApoB/apoA-I ratio.

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