Hepatoblastoma: Outcome of Management of Two Cases

Authors

  • Samuel Wabada Paediatric Surgery Unit, Department of Surgery, University of Maiduguri Teaching Hospital, Borno State, Nigeria
  • Jibril Khalil Paediatric Surgery Unit, Department of Surgery, University of Maiduguri Teaching Hospital, Borno State, Nigeria
  • Amos C. Zirra Paediatric Surgery Unit, Department of Surgery, University of Maiduguri Teaching Hospital, Borno State, Nigeria

Keywords:

Hepatoblastoma, Chemotherapy, Histology

Abstract

Even though hepatoblastoma is the most common malignant hepatic tumour in children, it is still a rarely encountered childhood tumour. Survival outcome is better with the favorable histologic subtype. This report is focused on raising increase awareness of this rare tumour in our environment and also to report the outcome of management of two cases based on already established collaborative multicentre clinical trial studies.

The first case was a 6week old girl with a painless abdominal mass presenting in acute respiratory distress with severe anaemia. The serum level of AFP was ≥ 107,000ng/ml. Right tri segmentectomy was performed for excision of the pedunculated liver mass. Histology of the mass was consistent with hepatoblastoma with predominance of fetal components. Complete course of adjuvant cisplatin 3mg/kg mono therapy was administered.

The second case was a 7 year old, healthy looking girl presenting with a slow growing abdominal mass for 6 years. Her serum AFP level was ≥ 10,000ng/ml. At surgery an encapsulated huge gray looking tumour was found on the right lobe of the liver. An extended right hepatectomy was performed to remove the tumour. Histology revealed hepatoblastoma with teratoid components. Complete course of adjuvant chemotherapy made up of cisplatin 60/mg2in combination with doxorubicin 30/mg2 was administered.

Both patients did well and had uneventful follow-ups.

Downloads

Published

2018-01-30

Issue

Vol. 4 (2017)

Section

Articles

License

Policy for Journals/Articles with Open Access

Authors who publish with this journal agree to the following terms:
    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work

Policy for Journals / Manuscript with Paid Access

Authors who publish with this journal agree to the following terms:
    1. Publisher retain copyright .

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .