Clinical Significance of Serum Vascular Endothelial Growth Factor Levels in Patients with Advanced Non-Small Cell Lung cancer

Authors

  • Serkan Degirmencioglu Pamukkale University Medicine Faculty Department of Medical Oncology
  • Erhan Ugurlu Pamukkale University Medicine Faculty Department of Medical Oncology
  • Arzu Yaren Pamukkale University Medicine Faculty Department of Thoracic Oncology

Keywords:

Lung cancer, VEGF, Prognosis, Survival, Diagnosis

Abstract

Objective: Due to poor prognosis in advanced non-small cell lung cancer (NSCLC), new markers and more effective treatment methods are needed in the monitoring of the disease. The purpose of our study is to evaluate the clinical significance of serum vascular endothelial growth factor (VEGF) levels in patients with advanced NSCLC on prognosis and survival.

Materials and method: Sixty seven patients (62 men and 5 women) and 20 healthy volunteers (16 men and 4 women) were included in our study. The demographic and laboratory data and serum VEGF levels of two groups were compared.

Results: A statistically significantly high level of VEGF (p=0.0001) was detected in patients compared to the control group. The high level of serum VEGF has a statistically significant relationship with the short disease-free survival time (p=0.05). While the median progression free survival (PFS) time in patients with high VEGF levels was 157 days, the median PFS time in those with normal VEGF levels reached up to 340 days. This difference was statistically significant (p=0.003). When overall survival (OS) times was evaluated, it was 472 days in patients with low VEGF levels and 180 days in those with high levels and the difference was statistically significant (p=0.001).

Conclusion: In our study, the serum VEGF levels were determined to be statistically significant increased in the NSCLC patient group compared to the control group. In addition, a significant inverse relationship was discovered between the serum VEGF level and all survival times in the NSCLC patient group.

Downloads

Published

2017-03-07

Issue

Vol. 4 (2017)

Section

Articles

License

Policy for Journals/Articles with Open Access

Authors who publish with this journal agree to the following terms:
    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work

Policy for Journals / Manuscript with Paid Access

Authors who publish with this journal agree to the following terms:
    1. Publisher retain copyright .

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .