https://cosmosscholars.com/phms/index.php/jtpr/issue/feed Journal of Translational Proteomics Research 2017-07-07T05:48:41+00:00 Support Manager support@cosmosscholars.com Open Journal Systems <p><strong>Journal of Translational Proteomics Research </strong>is a scientific journal providing a scholarly forum for novel scientific research in the field of translational proteomics. It covers all areas of human proteomics using multi-disciplinary approaches to untangle complex disease processes .Proteins are fundamental parts of living organisms, as they are the main components of the physiological metabolic pathways of cells. The cause of most human disease lies in the functional dysregulation of protein interactions. Proteomics, which includes the study of cellular protein interactions, has evolved from advances in scientific knowledge and technology.</p> https://cosmosscholars.com/phms/index.php/jtpr/article/view/757 Anti-DNA (“Cationic”) and Ani-Histone (“Anionic”) Auto- Antibodies: Two Sides of One Coin? 2017-06-22T06:07:15+00:00 Yuriy Kit kit@cellbiol.lviv.ua <p class="04-abstract">The mini review is focused on the analysis of published data and the results obtained by author with co-workers about biological activity of anti-DNA (“cationic”) and anti-histone Н1 (“anionic”) auto-antibodies linked with autoimmunity and oncology. The feathures of anti-DNA and-anti histone auto- antibodies, which might be engaged in regulation of tumor cell progressing, are considered.</p> 2017-06-21T00:00:00+00:00 Copyright (c) https://cosmosscholars.com/phms/index.php/jtpr/article/view/763 Combinational Synergy of Antibiotics and Antimicrobial Peptides 2017-07-07T05:48:41+00:00 Chien-Sheng Chen info@cosmosscholars.com Pramod Shah cchen103@gmail.com Combination of existing antibiotics have been introduced to increase the efficacy for a long time. Synergistic combinations of antibiotics are most desirable due to reduction of doses, toxicity and side effects of the individual antibiotic as well as prolonging in evolution of antibiotic resistance. Recently, antimicrobial peptides (AMPs) are gaining attention as viable alternatives to antibiotics due to the broad spectrum of activities and abundantly present in multicellular organisms that act against invading microbes. The combination of AMPs and conventional antibiotics enables to reduce the overall cost and widen the power of synergistic effects. Synergistic combinations are also reported among AMPs. Despite enormous advantages of synergistic combinations and several reports and uses in clinical medicine, only few underlying mechanisms are revealed. In this review, we overviewed the mechanisms of antimicrobial agents’ synergistic combinations and introduced the proteome chip approach for predicting new synergistic combinations and deciphering the synergy mechanisms. 2017-07-07T00:00:00+00:00 Copyright (c)

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        <full_title>Global Journal of Hematology and Blood Transfusion</full_title>
        <abbrev_title>GJHBT</abbrev_title>
        <issn media_type="electronic">2408-9877</issn>
      </journal_metadata>
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        <publication_date media_type="online">
          <month>07</month>
          <day>28</day>
          <year>2016</year>
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          <volume>3</volume>
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        <issue>2</issue>
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        <titles>
          <title>Is there any Relationship between Rh(D) Blood Group and Von Willebrand Factor Antigen Concentration?</title>
        </titles>
        <contributors>
          <person_name contributor_role="author" sequence="first" language="en">
            <given_name>I. S.</given_name>
            <surname>Akpan</surname>
          </person_name>
          <person_name contributor_role="author" sequence="additional" language="en">
            <given_name>E. M.</given_name>
            <surname>Essien</surname>
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          <jats:p>Background: Several reports have documented the influence of ABO blood group on plasma von Willebrand Factor Antigen (vWF:Ag) levels. However, a thorough search through the literature has not revealed any study on the relationship between Rh blood group and plasma von Willebrand Factor antigen levels.
Objective: The aim of this study was to determine the relationship between plasma vWF:Ag levels and Rh(D) blood group among apparently healthy Nigerian subjects.
Methods: This was a cohort study of 100 Blood Donors attending the Blood Bank Unit at University of Uyo Teaching Hospital, Uyo, Nigeria. Plasma vWF:Ag levels were determined by ELISA method while the ABO and Rh(D) blood group phenotypes were determined using the standard tube method. The data were analyzed with SPSS version 16.0. Chi square was used for test of significance.
Results: The study population consisted of 63 (63%) males and 37 (37%) females with a mean age of 31.7 ± 6.39 years. The frequency of Rh(D) positive and Rh(D) negative blood groups were 95% and 5%, respectively. The mean plasma vWF:Ag concentration of the subjects was 1.38 ± 1.02 IU/ml. Group B Rh(D) positive subjects had the highest mean vWF:Ag level (2.27 ± 1.57 IU/ml), followed by group O Rh (D) negative (2.00 ± 1.04 IU/ml), group AB Rh(D) positive (1.69 ± 1.06 IU/ml), group B Rh(D) negative (1.53 ± 0.57 IU/ml), group O Rh(D) positive (1.24 ± 1.00 IU/ml) and group A Rh(D) positive (1.08 ± 0.40 IU/ml) having the lowest level.
Conclusion: There was no statistically significant association between the plasma vWF:Ag levels and Rh(D) blood groups of study subjects (P = 0.1546). However, further research with larger sample size is required to determine the relationship between plasma vWF:Ag levels and Rh blood group in general before reaching definite conclusion about the lack of influence of Rh blood group on the plasma level of vWF:Ag.</jats:p>
        </jats:abstract>
        <publication_date media_type="online">
          <month>07</month>
          <day>28</day>
          <year>2016</year>
        </publication_date>
        <pages>
          <first_page>43</first_page>
          <last_page>47</last_page>
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