Combinational Synergy of Antibiotics and Antimicrobial Peptides

Authors

  • Chien-Sheng Chen Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli 32001, Taiwan
  • Pramod Shah Graduate Institute of Systems Biology and Bioinformatics, National Central University, Jhongli 32001, Taiwan

Keywords:

Synergistic, Combination, Antibiotic, Antimicrobial peptide, Mechanism, Target analysis

Abstract

Combination of existing antibiotics have been introduced to increase the efficacy for a long time. Synergistic combinations of antibiotics are most desirable due to reduction of doses, toxicity and side effects of the individual antibiotic as well as prolonging in evolution of antibiotic resistance. Recently, antimicrobial peptides (AMPs) are gaining attention as viable alternatives to antibiotics due to the broad spectrum of activities and abundantly present in multicellular organisms that act against invading microbes. The combination of AMPs and conventional antibiotics enables to reduce the overall cost and widen the power of synergistic effects. Synergistic combinations are also reported among AMPs. Despite enormous advantages of synergistic combinations and several reports and uses in clinical medicine, only few underlying mechanisms are revealed. In this review, we overviewed the mechanisms of antimicrobial agents’ synergistic combinations and introduced the proteome chip approach for predicting new synergistic combinations and deciphering the synergy mechanisms.

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Published

2017-07-07

Issue

Vol. 3 (2017)

Section

Articles

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