The Correlations Between TNF System and Memories in Chronic Insomnia Disorder

Authors

  • Chen Gui-Hai Department of Neurology , the Affiliated Chaohu Hospital of Anhui Medical University, Hefei (Chaohu)
  • Xia Lan Department of Neurology, the Second Affiliated Hospital of Anhui Medical University
  • Ge Yi-Jun Department of Neurology , the Affiliated Chaohu Hospital of Anhui Medical University
  • Wang Fang Department of Neurology, the First Affiliated Hospital of Anhui Medical University
  • Qu Ping Department of Neurology, the Second Affiliated Hospital of Anhui Medical University

Keywords:

Chronic insomnia disorder, Tumor necrosis factor, Soluble receptor, Memory

Abstract

Objectives: To explore the changes of serum levels of tumor necrosis factors (TNF-α and TNF-β) and their soluble receptors (sTNF-R1 and sTNF-R2), and analyze their relationship between sleep quality and memory in the patients with chronic insomnia disorder (CID).

Methods: Forty-four CID patients and 39 normal controls were enrolled in this study. Pittsburgh Sleep Quality Index (PSQI) and Nine-Box Maze Test (9BMT) were used to assess the sleep quality and memory function, respectively. The serum levels of TNF-α, TNF-β, sTNF-R1 and sTNF-R2 were examined by protein-chip.

Results: Compared to the controls, the CID patients had significantly higher error numbers of the spatial working and object recognition memories (Ps < 0.05) in the 9BMT, with higher serum levels of TNF-α and TNF-β (Ps < 0.001), and lower levels of sTNF-R1 and sTNF-R2 (Ps < 0.001). The partial correlation analysis showed that the serum TNF-α and TNF-β positively but sTNF-R1 and sTNF-R2 negatively correlated with PSQI scores (Ps < 0.001). In the CID patients, the TNF-α positively correlated with the errors in the spatial working and object recognition memories (Ps < 0.05), whereas the TNF-β only positively correlated with the errors in the spatial working memory (P < 0.05).

Conclusions: The CID patients had increased TNF-α and TNF-β and decreased sTNF-R1 and sTNF-R2 in peripheral blood, with the former being linked to specific memory impairments.

Downloads

Published

2020-02-01

Issue

Vol. 7 No. 1 (2020)

Section

Articles

License

Policy for Journals/Articles with Open Access

Authors who publish with this journal agree to the following terms:
    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work

Policy for Journals / Manuscript with Paid Access

Authors who publish with this journal agree to the following terms:
    1. Publisher retain copyright .

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .