Neuroprotective Effects of Rhamnazin as a Flavonoid on Chronic Stress-Induced Cognitive Impairment


  • Saeed Mohammadi Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
  • Yosef Golshani Department of Biology, Payam-Noor University, Hamadan Branch, Hamadan, Iran


Flavonoids, Stress, Learning, Memory, Neuroprotective


The aim of the present examination was to research the conceivable impacts of chronic administration of rhamnazin, on constant stress instigated learning and memory impairment in rodent. The rats were controlled every day 4 h/day for 30 days in very much ventilated plexiglass tubes without access to nourishment and water. These creatures were infused with rhamnazin or vehicle worry over a time of 30 days. At that point, spatial learning and memory of the rodent were assessed by the Morris water maze. We didn't watch a noteworthy contrast in the escape inactivity in rodent subjected to rehashed restriction push, which shows that learning capacity was not influenced by limitation stress. Be that as it may, the spatial memory capacity was essentially disabled in the over and again limited rodent. Rhamnazin administration particularly expanded the time spent in the objective quadrant in rodent presented to chronic stress in the probe trial as tried in the Morris water maze. Additionally contemplates demonstrated that rhamnazin treatment diminished plasma adrenocorticotrophic hormone levels (ACTH) of those rats subjected to rehashed restriction push. The impact of rhamnazin on the levels of mind inferred neurotrophic factor (BDNF) in hippocampus was likewise researched. The outcome demonstrated that rhamnazin standardized the diminished BDNF levels in rodent subjected to rehashed limitation push. These discoveries give more confirmation that ceaseless administration of rhamnazin enhances spatial memory in over and over controlled rodent and BDNF motioning in the hippocampus might be included in the defensive impacts of rhamnazin