The Thioredoxins Protein System: a Key Target in Perinatal Asphyxia

Authors

  • Francisco Capani Instituto de Investigaciones Cardiológicas (ININCA), Facultad de Medicina, UBA-CONICET
  • Tamara Logica Tornatore Instituto de Investigaciones Cardiológicas (ININCA), Facultad de Medicina, UBA-CONICET
  • Eduardo Blanco Unidad de Gestión Clínica de Salud Mental, Laboratorio de Medicina Regenerativa, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga Málaga, Spain; Departament de Pedagogia i Psicologia, Facultat d'Educació, Psicologia i Treball Social, Universitat de Lleida Lleida,
  • Marìa Herrera Instituto de Investigaciones Cardiológicas (ININCA), Facultad de Medicina, UBA-CONICET
  • Rodolfo Kolliker Instituto de Investigaciones Cardiológicas (ININCA), Facultad de Medicina, UBA-CONICET
  • George Barreto Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana

Keywords:

Trxs protein family, Perinatal asphyxia, Neuroprotection, Redox regulation, Central nervous system, Retina

Abstract

Hypoxia during birth is one of the leading childhood mortality worldwide and results in many neurodisabled survivors. Several lines of evidence demonstrated that reactive oxygen species are the final step in the metabolic disorders produced by a deficit of oxygen. However, any specific therapy has been effective to ameliorate the devastating consequences of perinatal asphyxia. In the last few years, the Thioredoxin Family Protein has emerged as a key player in the regulation of the redox state of the cells in normal and pathological conditions. This review summarizes new insight of the role of Trxs, Prxs and Grxs in physiopathology of perinatal asphyxia.

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Published

2016-04-29

Issue

Vol. 3 No. 1 (2016)

Section

Articles

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