Restorative Effect of Distillated Nerium Oleander Extract on Diabetic Neuropathy: Animal Model Study

Authors

  • Sirma Basak Yanardag Selçuk University Medical Faculty Department of Biophysics
  • Ahmet Akkoca Selçuk University Medical Faculty Department of Biophysics
  • Figen Çiçek Figen Çiçek Çukurova University Faculty of Medicine Department of Biophysics
  • Murat Ayaz Selçuk University Medical Faculty Department of Biophysics

Keywords:

Type II Diabetes, Neuropathy, Nerium oleander, Rat, Sciatic Nerve

Abstract

The current study aims to investigate the possible role of Nerium oleander (NeOL) distillate in the treatment of diabetic neuropathy. The restorative affects of distillated NeOL on the diabetes-induced electrophysiological alterations were investigated. Induction of diabetes was done by the combination of single dose streptozotocin injection together with a high fat diet for four weeks. Experimental groups were designed as follows: control, diabetic, and NeOL treated diabetic. Nerve conduction velocity (CV) recordings were performed through a suction electrode from the tibia branch of the sciatic nerve trunk. Diabetes results an increase in rheobase, chronaxie values together with a decrease in maximum depolarization (MD), compound action potential (CAP) area and CV measurements. With its antioxidant nature, NeOL treatment produced nearly complete restorations of the diabetes-induced alterations. Current study has shown that distillated NeOL (375 µg /0.5 ml dH2O /day) can be a highly potential therapeutic agent on the diabetes induced alterations.

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Published

2015-10-29

Issue

Vol. 2 No. 2 (2015)

Section

Articles

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