Natural Hydroxyapatite Ca5(PO4)3OH: An Efficient Catalyst for the Chemo- and Regioselective Enamination of the β-Ketoesters

Authors

  • Abdelhadi Louroubi Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Université Cadi Ayyad, Faculté des Sciences Semlalia
  • Halima Ouahine Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Université Cadi Ayyad, Faculté des Sciences Semlalia
  • Brahim Boualy Laboratoire de Chimie et Modélisation Mathématique, Université Hassan 1er, Faculté Polydisciplinaire de Khouribga
  • Mustapha Ait Ali Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Université Cadi Ayyad, Faculté des Sciences Semlalia
  • Larbi El Firdoussi Equipe de Chimie de Coordination et Catalyse, Département de Chimie, Université Cadi Ayyad, Faculté des Sciences Semlalia

Keywords:

Hydroxyapatite, Catalyst, Condensation, β-enaminoester, Solvent free

Abstract

Hydroxylapatite or hydroxyapatite Ca5(PO4)3OH (Hap), a natural mineral species of the family of phosphate, efficiently catalyzed the condensation of 1,3-ketoesters with primary amines under solvent-free conditions. The reaction was complete in 10 min, to afford β-enamino esters in a high yield and good selectivity. Moreover, the catalyst can be re-used for four times with good activities.

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Published

2016-10-27

Issue

Vol. 3 No. 2 (2016)

Section

Articles

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