One-Pot Transformation of Olefins into -Aminoalcohols Via Vic- Bromohydrins Catalyzed by Silica
Keywords:
-Aminoalcohol, Bromohydroxylation, Morpholine, Olefins, One-pot synthesis, Silica.Abstract
Commercially available silica (SiO2) was found to be highly effective catalyst for one-pot synthesis of a-aminoalcohols from olefins via bromohydrins using morpholine as nitrogen fragment donor. Furthermore, silica in the presence of easily accessible N-bromosuccimide (NBS) catalyzes a rapid and quantitative room temperature bromohydroxylation of simple olefins. Various olefins are easily converted to the corresponding vic-bromohydrins and in “one pot†to a-aminoalcohols in excellent yields and high selectivity. The reaction offers a simple and efficient method for the preparation of vic-bromohydrins and a-aminoalcohools.Downloads
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2014-11-25
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