Personalized Dosimetry for <sup>188</sup>Re Radionuclide Therapies Based on Post-Treatment SPECT/CT Scans

Authors

  • Anna Celler Department of Radiology, University of British Columbia, Vancouver, BC, V5Z 1M9, Canada
  • Pedro L. Esquinas Department of Physics and Astronomy, University of British Columbia, Vancouver, BC, V6T 1Z1, Canada

Keywords:

Rhenium-188, Radionuclide therapies, Quantitative SPECT, Image segmentation, dosimetry

Abstract

Over the last three decades, Rhenium-188 (188Re) applications in Nuclear Medicine therapies have gathered a lot of interest thanks to the favorable physical and chemical characteristics of this isotope. In order to optimize 188Re therapies, the accurate knowledge of the activity distribution within the patient body is required. To this end, the nuclear medicine images must yield accurate quantitative measurements. However, the decay of 188Re results in a large variety of emissions such as β-particles, γ-particles and Bremsstrahlung, making quantitative measurements of 188Re activity a very difficult task. In this paper, we discuss the imaging protocols, data acquisitions, techniques used in image reconstruction and processing, and dose estimation methods required for accurate, image-based, personalized dosimetry for molecular therapies with 188Re.

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Published

2017-07-31

Issue

2017: Special Issue - 188Rhenium, the new Workhorse of Radio Nuclide Therapy: Concepts to Clinical Use

Section

Articles

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