Development of A New Radiogallium Porphyrin Complex as A Possible Tumor Imaging Agent

Authors

  • Yousef Fazaeli Nuclear Science and Technology Research Institute
  • Amir R. Jalilian Nuclear Science and Technology Research Institute
  • Ali Khalaj Tehran University of Medical Sciences

Keywords:

Porphyrins, Ga-67, Biodistribution, Imaging agent, SPECT.

Abstract

Introduction: Developing imaging agents based on novel porphyrin pharmacophores is of great interest based on interesting biological/pharmacological performance when labeled with various radionuclides.

Method: [67Ga] labeled 5,10,15,20-tetrakis (pentafluorophenyl) porphyrin ([67Ga]- TFPP) was prepared using [67Ga]GaCl3 and 5,10,15,20-tetrakis (pentafluorophenyl) porphyrin (H2TFPP) for 60 min at reflux condition followed by stability tests, partition coefficient determination as well as bio distribution tudies in wild type and tumor bearing animals using scarification and SPECT imaging.

Result: The complex was prepared with acceptable radiochemical purity (>97% ITLC, >98% HPLC, specific activity: 13-14 GBq/mmol) and stability in final formulation and human serum for 24 h. The partition coefficient was 0.69 (log P). The tumor:blood and tumor:muscle uptake ratios were 24.5 and 61.25 respectively after 48 h demonstrating significant tumor-imaging property of the tracer. Also confirmed by SPECT imaging. Conclusion: The tracer can be an interesting tumor imaging agent due to high specific uptake and rapid excretion through the urinary tract.

Author Biographies

Yousef Fazaeli, Nuclear Science and Technology Research Institute

Radiation Application Research School

Amir R. Jalilian, Nuclear Science and Technology Research Institute

Radiation Application Research School

Ali Khalaj, Tehran University of Medical Sciences

Nuclear Pharmacy

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Published

2015-03-20

Issue

Vol. 2 No. 1 (2015)

Section

Articles

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