Synergistic hepatoprotective effects of co-administration of Garcinia kola extract and Tarivid in Acetaminophen-induced hepatotoxicity

Abstract

Hepatotoxicity is a major concern in clinical practice, and current treatments have limitations. Garcinia kola extract (GKE) and Tarivid (a fluoroquinolone antibiotic) have individual hepatoprotective properties. This study investigated the synergistic effects of co-administering GKE and Tarivid in acetaminophen-induced hepatotoxicity. 36 Wistar rats were divided into six groups: control, acetaminophen-induced hepatotoxicity, GKE-treated, Tarivid-treated, co-administered GKE and Tarivid, and standard drug (silymarin)-treated. Biochemical markers (ALT, AST and ALP) and histopathological examinations were conducted. Co-administration of GKE and Tarivid significantly reduced biochemical markers (p < 0.05) and exhibited improved histopathological profiles compared to individual treatments. The combination showed enhanced antioxidant activity and reduced oxidative stress: Co-administration of Garcinia kola extract and Tarivid demonstrates synergistic hepatoprotective effects, offering a potential therapeutic strategy for managing hepatotoxicity. Further studies are warranted to explore the clinical applications of this combination.