Formulation, Development and Investigation of Matrix Type Sustained Release Tablet of Antiulcer Drug by Using Soluble Polymer as a Drug Release Retarding Agent

Authors

  • Satbir Singh Research Scholar, Department of Pharmacy, Sunrise University, Alwar, Rajasthan
  • Gaikwad Dushyant Dadabhau Professor, Department of Pharmacy, Sunrise University, Alwar, Rajasthan
  • Kehar Singh Research Scholar, Department of Pharmacy, Sunrise University, Alwar, Rajasthan

DOI:

https://doi.org/10.15379/ijmst.v10i4.3701

Keywords:

Sustained Release, Drug Release, Nizatidine, Pre-formulation, characterization, post compression parameters

Abstract

The main goals of sustained release drug delivery are to modify the medication's biopharmaceutical, pharmacokinetic, and pharmacodynamic properties in order to lessen adverse effects, increase patient compliance, and treat the illness. The current work set out to create sustained release tablets of nizatidine (220 mg) using a wet granulation process and different concentrations of polymers such as chitosan, Kollidon SR, and HPMC K100M. Pre-formulation characteristics were examined, including medication DSC analysis and FTIR research. We assessed a number of post-compression characteristics, including content homogeneity, thickness, hardness, friability, and weight uniformity. This study demonstrated how the post-compression characteristics of the drug formulation are influenced by the concentration of polymers.

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Published

2023-09-22

How to Cite

[1]
S. . Singh, G. D. . Dadabhau, and K. . Singh, “Formulation, Development and Investigation of Matrix Type Sustained Release Tablet of Antiulcer Drug by Using Soluble Polymer as a Drug Release Retarding Agent”, ijmst, vol. 10, no. 4, pp. 2593-2603, Sep. 2023.

Issue

Vol. 10 No. 4 (2023): Continuous publication

Section

Articles

License

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