“Novel Diiodobenzaldehyde Derivatives of 4-Aminopyrrolo[2,3-d] pyrimidine: Synthesis, Characterization, and Biological Activity.”

Abstract

The main objectives of this study were to create new pyrrolopyrimidine compounds, analyze their properties, and assess their effectiveness against both fungi and bacteria. Specifically, the focus was on synthesizing diiodobenzaldehyde derivatives of pyrrolopyrimidine. Various spectroscopic methods were employed to characterize the chemically synthesized substances. These compounds were then tested for their ability to inhibit the growth of four bacterial strains (S. aureus, B. subtilis, E. coli, P. aeruginosa) and two fungal strains (C. albicans, S. cerevisiae). Each synthesized compound exhibited distinct peaks in FT(IR), ¹H, and ¹³C NMR, as well as UV spectral studies. In vitro testing revealed that compound 2a displayed significantly higher antibacterial and antifungal activity compared to streptomycin and fluconazole, the gold standards.