Nanomaterials Drug Delivery System in Herbal Formulation For Antidiabetic Activity: A Review

Abstract

Diabetes, a chronic metabolic disorder, results in high blood glucose levels due to insufficient insulin production or ineffective insulin utilization. Management entails lifestyle changes, exercise, and medication adherence. Monitoring blood sugar levels, healthy eating, and medication are crucial for controlling diabetes and preventing complications. The illness, currently incurable, necessitates management strategies for regulation. Medical treatments are expensive and require long-term adherence, leading many, especially those from low-income nations, to resort to herbal remedies. However, phytocompounds, though promising, often suffer from limited bioavailability due to poor solubility, permeability, or rapid elimination. Plant nanomedicines offer a promising avenue to address these challenges and alleviate the financial strain on disadvantaged populations. Encapsulated treatments using plant extracts or antidiabetic chemicals at the nanoscale have shown promising results. Our study aims to provide a thorough examination of lipid- and inorganic-based nanoparticulate delivery systems combined with plant extracts or phytocompounds for diabetes management Our analysis will highlight both the advantages and limitations of these systems for future clinical application. Examined studies revealed that nanoparticulate formulations displayed strong antidiabetic effects at lower doses compared to individual plant extracts or phytocompounds. Additionally, nanoparticulate systems have effectively addressed the issue of low bioavailability in herbal medications, showing promise for enhanced therapeutic outcomes.