Preparation Of Diosgenin-Encapsulated Microspheres By Spray Drying Technique

Abstract

Diosgenin, a naturally occurring steroid sapogenin possessing diverse therapeutic properties, represents a bioactive compound of interest. However, its complete pharmaceutical utilization has been impeded by inherent challenges, primarily associated with poor aqueous solubility and stability. In the present investigation, we introduce an innovative methodology for fabricating diosgenin-encapsulated microspheres through the utilization of the spray drying technique. The spray drying process involves the transformation of a solution containing diosgenin into finely dispersed microspheres through atomization, followed by rapid drying in a hot air stream. Various formulation parameters, encompassing the selection of encapsulating material, surfactants, and process conditions, were methodically optimized to attain elevated encapsulation efficiency and precise control over release characteristics. The microspheres thus prepared underwent assessment for percentage yield, encapsulation efficiency, particle size, and in vitro drug release. Results indicate the generation of uniform microspheres exhibiting heightened diosgenin encapsulation and enhanced physical stability. Additionally, in vitro release studies demonstrated sustained and controlled diosgenin release from the microspheres, underscoring their potential for protracted therapeutic effects. Encapsulation efficiency, release kinetics, and physicochemical attributes of the microspheres were found to be contingent upon the choice of encapsulating material and process parameters. In conclusion, the fabrication of diosgenin-encapsulated microspheres employing the spray drying technique represents a promising strategy to augment the bioavailability and therapeutic efficacy of diosgenin. These microspheres hold considerable promise for applications within the pharmaceutical and nutraceuticals industries serving as a platform for the advancement of innovative drug delivery systems.