Elevation of Plasma Malondialdehyde Levels Associated with The Severity of Coronary Atherosclerosis in Coronary Artery Disease Patients

Abstract

The present study aims to investigate the relationship between plasma MDA and the severity of coronary artery disease in CAD patients. A total of 159 newly diagnosed CAD patients were enrolled in the study with an average age of 65.5 ± 11.3 years old and 63% were male. Participants underwent an investigation of blood biochemistry and plasma MDA before the measurement of coronary artery angiography. They were then divided into four groups as control (non-CAD), single vessel disease (SVD), double vessel disease (DVD), and triple vessel disease (TVD) groups. The results showed high plasma MDA levels were observed in SVD, DVD, and TVD patients (1.64 ± 0.56, 2.32 ± 0.57, 2.52 ± 0.76, respectively) when compared with the control group (1.44 ± 0.54, P < 0.001). Interestingly, plasma MDA was associated with fasting blood glucose (r = 0.183, P = 0.024), total cholesterol (r = 0.231, P = 0.004), triglyceride levels (r = 0.269, P < 0.001), HDL-cholesterol levels (r = -0.221, P = 0.006), and LDL-cholesterol levels (r = 0.164, P = 0.044). ROC analysis was performed using both control and CAD patients as subjects. The cut-off for plasma MDA was 1.624 ?mol/L with 83.6% sensitivity and 28.0% specificity. The findings of this research showed that plasma MDA levels were associated with the severity of CAD.