Gemcitabine (A Chemotherapy Medication) Vs. Phytochemicals Against Non-Small Cell Lung Cancer – A Computational Approach

Abstract

Non-small cell lung cancer is a type of lung cancer, where healthy cells in the lungs grow out of control forming a tumor or a nodule. Although small cell lung cancer and non-small cell lung cancer share few common symptoms and causes, their rate of spread or metastasis differs significantly. Targeted gene therapies involving uses of targeted drugs against specific gene or protein are increasingly being used for the treatment of lung cancer. This study aims at understanding the efficacy of the bioactive compounds over the already existing chemotherapy drug- Gemcitabine. For this study, the target receptor proteins of Non-Small Cell Lung Cancer (NSCLC) were retrieved from Protein Data Bank (PDB) and the ligand compounds were retrieved using PubChem NCBI. Based on various research studies, four target proteins from NSCLC and sixteen bioactive compounds of Curculigoorchioides (Black musale) were selected. And their effect of bioactive compounds has been studied by means of in-silico approach and further the identified potential active compounds have been compared with control. This comparative in-silico study has predicted that the bioactive principle of Curculigoorchioides has better efficacy against cancer receptors and can considered as an effective alternative drug for cancer treatment. Concluding, the present study will be useful in future for designing novel therapeutic plant-based drug with higher efficacy for the treatment of lung cancer.