Computational Modeling, Molecular Docking, Pharmacokinetic & Toxicological Studies of 1, 5- Diphenyl-2, 4-Disubstituted- 1H-Imidazole for Antioxidant Activity

Authors

  • Sonawane Rutuja Research Scholar, Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies, VISTAS, Pallavaram, Chennai, Tamil Nadu, India,... Department of Pharmaceutical Chemistry, SCES’s Indira College of Pharmacy, Tathawade, Pune, India
  • K. Karthickeyan Professor and Head, Ph.D. Guide, Department of Pharmacy Practice, School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Pallavaram, Chennai, India

DOI:

https://doi.org/10.15379/ijmst.v10i4.2412

Keywords:

Molecular docking, ADMET Studies, in-vitro anti-oxidant activity, 2HCK, 1HD2, 1H-Imidazole, Pharmacokinetic properties, toxicological studies

Abstract

Series of 1, 5-Diphenyl-2, 4-disubstituted- 1H-Imidazole were produced Computationally and evaluated for their in vitro antioxidant activities and were compared with the standard drug. ?-Tocopherol. A molecular docking study was also carried out against particular protein tyrosine kinase (2HCK) and peroxiredoxin (1HD2) were obtained from PDB data bank to predict the interaction between the compounds and protein. The physicochemical and pharmacokinetic parameters were computationally performed to predict the parameters of absorption, distribution, metabolism, excretion, and toxicity (ADMET).

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Published

2023-10-05

How to Cite

[1]
S. . Rutuja and K. . Karthickeyan, “Computational Modeling, Molecular Docking, Pharmacokinetic & Toxicological Studies of 1, 5- Diphenyl-2, 4-Disubstituted- 1H-Imidazole for Antioxidant Activity”, ijmst, vol. 10, no. 4, pp. 2303-2311, Oct. 2023.

Issue

Vol. 10 No. 4 (2023): Continuous publication

Section

Articles

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