EFFICACY OF ULTRASONIC TRANSDERMAL PLATELET RICH PLASMA ON CHRONIC LOWER LIMB VENOUS ULCER HEALING

Abstract

The present study was carried-out to examine the impact of Ultrasonic Transdermal Delivery of platelet rich plasma (PRP)on chronic lower limb venous ulcer healing. Design: Randomized controlled trial. Patients and methods: The present work was conducted on sixty patients with chronic lower limb venous ulcers who took-part in this study, they aged from 40 to 60 years. The participants were recruited from Mataria teaching hospital and were randomized into two groups; each group consisted of 30 patients. Group A (Ultrasonic PRP group) received Ultrasonic Transdermal Delivery of autologous PRP twice weekly for a month in addition to medical care and group B (Control group) received medical care in form of antimicrobial dressing, wound care and debridement of ulcers. Saline method was used to measure the ulcer volume. Digital photography/imaging and surface area estimation software (Image J) was used to measure ulcer surface area. Results: After treatment, there was significant decline in wound surface area as well as volume of PRP group in comparison with the control group (p < 0.001). Conclusion: Adding Ultrasonic transdermal delivery of platelets rich plasma to medical treatment of chronic venous ulcer can enhance healing process by reducing surface area and ulcer volume and it is considered a safe, simple, inexpensive and cost effective modality.