Synthesis, Molecular Docking Studies and Cytotoxic Screening of Novel 2-Substituted Benzimidazole Derivatives

Authors

  • Rani S. Kankate Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik 422003, Maharashtra, India
  • Sunita Surse Department of Pharmacognosy, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik 422003, Maharashtra, India
  • Pooja Abhang Department of Pharmaceutical Chemistry, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik 422003, Maharashtra, India
  • Smita Kakad Department of Pharmaceutics, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik 422003, Maharashtra, India
  • Sanjay Kshirsagar Department of Pharmaceutics, MET’s Institute of Pharmacy, Bhujbal Knowledge City, Nashik 422003, Maharashtra, India

DOI:

https://doi.org/10.15379/ijmst.v10i3.1999

Keywords:

Anticancer, Benzimidazole, Bendamustine, Cytotoxic Activity, Oxazole, 5FGK

Abstract

Cancer is one of the most serious lifethreatening diseases for which there is presently no cure. According to current World Health Organization (WHO) reports cancer is responsible for one out of every six deaths worldwide. Benzimidazole is a heterocyclic, aromatic molecule that acts as a biological scaffold with anticancer, antitumor, and antiproliferative activities, among other biological effects. benzimidazole and oxazole are the important pharmacophore in the medicinal chemistry, due to their widespread pharmacological activities. So, to exploit their anticancer potential we have selected these two for our research work. So, in order to develop potential anticancer agents, it was considered of interest to synthesize some benzimidazole derivatives. Before synthesis of molecule, Molecular docking was done and afterwards the compound with lowest dock score selected for synthesis. Synthesized derivatives Characterized By Proton Nuclear Magnetic Resonance (1H NMR), Infra-Red (IR), And Mass Spectroscopy (MS) and screen for cytotoxic activity.

Downloads

Download data is not yet available.

Downloads

Published

2023-09-19

How to Cite

[1]
R. S. . Kankate, S. . Surse, P. . Abhang, S. . Kakad, and S. . Kshirsagar, “Synthesis, Molecular Docking Studies and Cytotoxic Screening of Novel 2-Substituted Benzimidazole Derivatives ”, ijmst, vol. 10, no. 3, pp. 2568-2579, Sep. 2023.

Similar Articles

You may also start an advanced similarity search for this article.