Determination of Free Chemical Potential for Finasteride Diffusion through SDS Micelle Suggested as Alternative Living Membrane System

Abstract

Abstract: As an alternative living cell membrane, sodium dodecyl sulfide (SDS) has been investigated at this study, spectroscopic assessment of Finasteride diffusion through the alternate model of the cell membrane in two distinct polar solutions, buffer phosphate solution pH 7.4 and Cyclohexane(Non-polar solution), has been studied. Finasteride in buffer phosphate solution showed a definite ?_max at 253 nm, which was consistent with the default values. The results also reveal that the non-polar medium has a lower attenuation coefficient and a shorter maximum wavelength than the polar medium. The pH 7.4 finasteride solution demonstrated remarkable stability over time.

Diffusion rate of Finasteride was investigated using Sodium Dodecyl Sulfate (SDS) as an alternative cell membrane model. The chemical potential was determined to be - 6294.76 J mol^-1, showing the spontaneity of the compound's diffusion process.

The results indicated that Finasteride may diffuse (at a rate constant of 51.11 min^-1) from the aqueous media and other identified components to the inner micelle; the equilibrium constant for diffusion was calculated to be 11.5.

Keywords: Finasteride, Diffusion, Chemical potential, SDS, Alternative model, Cell membrane.