Effects of Physical Activity on The Inflammatory Process Related to Insulin Resistance and Obesity

Authors

  • Aline Marcadenti Federal University of Health Sciences of Porto Alegre
  • Francisca Mosele Federal University of Rio Grande do Sul. Porto Alegre
  • Mirna Stela Ludwig Regional University of Northwestern Rio Grande do Sul State
  • Thiago Gomes Heck Regional University of Northwestern Rio Grande do Sul State
  • Erlon Oliveira de Abreu-Silva Federal University of Sao Paulo

Keywords:

Inflammation, Endothelial dysfunction, Obesity, Insulin resistance, Exercise.

Abstract

Atherosclerosis, the pathophysiological substrate for cardiovascular disease (CVD), is the final stage of an inflammatory cascade. During the process, endothelial dysfunction ensues and the inflammatory state is perpetuated. A number of traditional risk factors, as obesity and insulin resistance/type 2 diabetes, are characterized by a proinflammatory state as well, with increased levels of cytokines, interleukins, vasoactive peptides and enhanced expression of specific cellular receptors. The anti-inflammatory properties of physical exercise and its positive effects as a strategy for obesity and insulin resistance have already been shown in terms of cardiovascular protection and survival.

Author Biographies

Aline Marcadenti, Federal University of Health Sciences of Porto Alegre

Nutrition

Francisca Mosele, Federal University of Rio Grande do Sul. Porto Alegre

Post-graduation Program in Epidemiology

Mirna Stela Ludwig, Regional University of Northwestern Rio Grande do Sul State

Research Group in Physiology, Department of Life Sciences

Thiago Gomes Heck, Regional University of Northwestern Rio Grande do Sul State

Life Sciences

Erlon Oliveira de Abreu-Silva, Federal University of Sao Paulo

Interventional Cardiology and Post-graduation Program in Cardiology

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Published

2015-03-21

Issue

Vol. 2 No. 1 (2015)

Section

Articles

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