Approach to Aplastic Anemia- An Overview and Practical Approach

Authors

  • Anuradha Vutukuru Department of Pathology, PMC, Karimnagar, India
  • Attili Vs Suresh Department of Medical Oncology, SVS Medical College, Mehaboobnagar, India

DOI:

https://doi.org/10.15379/2408-9877.2016.03.02.05

Keywords:

Aplastic anemia, Etiology, Transplant, Cytopenia, Management

Abstract

Despite the fact that cytopenia has been a common hematological entity seen in clinical practice for decades, the understanding of its etiopathogenesis has been changing, which in turn impacts on the management strategies. The current review focuses on the understanding of the current concepts and a brief overview of the management of aplastic anemia. As the spectrum of stem cell biology, etiology, and treatment from transplantation to graft-versus-host disease cannot be covered in few paragraphs, the most concise form is presented here.

References

Andrea Bacigalupo MD, Ospedale S. Martino. Aplastic Anemia: Pathogenesis and Treatment. Hematology Am Soc Hematol Educ Program 2007: 23-8. http://dx.doi.org/10.1182/asheducation-2007.1.23

Aplastic anemia: seed or soil [editorial]. Lancet 1977; 8041: 748-750.

Young NS, Calado RT, Scheinberg P. Current concepts in the pathophysiology and treatment of aplastic anemia Blood 2006; 108: 2509-2519. http://dx.doi.org/10.1182/blood-2006-03-010777

Maxwell M Wintrobe, John P Greer. Wintrobe's clinical hematology Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins 2009; 1172-1189.

Rai M, Singh VP, Shukla J, Sundar S, Jha VC. Low dose cyclosporine-a therapy in severe aplastic anaemia. J Assoc Physicians India 2001; 49: 966-9.

Gluckman E, Rokicka-Milewska R, Hann I, et al. Results and follow-up of a phase III randomized study of recombinant human-granulocyte stimulating factor as support for immunosuppressive therapy in patients with severe aplastic anaemia Br J Haematol 2002; 119: 1075-1082. http://dx.doi.org/10.1046/j.1365-2141.2002.03947.x

Locasciulli A, Bruno B, Rambaldi A, et al. Treatment of severe aplastic anemia with anti-lymphocyte globulin, cyclosporine and two different granulocyte colony stimulating factor regimens: a GITMO prospective randomized study Haematologica 2004; 89: 1054-1061.

Socie G, Mary JY, Schrezenmeier H, et al. Granulocyte-stimulating factor and severe aplastic anemia: a survey by the European Group for Blood and marrow Transplantation (EBMT) Blood 2007; 109: 2794-2796.

Olnes MJ, Scheinberg P, Calvo KR, et al. (2012) Eltrombopag and improved hematopoiesis in refractory aplastic anemia. N Engl J Med 367(1): 11-19. http://dx.doi.org/10.1056/NEJMoa1200931

Neal S. Young. Current concepts in the pathophysiology and treatment of aplastic anemia. Hematology 2013; 76-81.

Locasciulli A, Bruno B, Rambaldi A, et al. Treatment of severe aplastic anemia with anti-lymphocyte globulin, cyclosporine and two different granulocyte colony stimulating factor regimens: a GITMO prospective randomized study Haematologica 2004; 89: 1054-1061.

Teramura M, Kimura A, Iwase S, et al. Treatment of severe aplastic anemia with antithymocyte globulin and cyclosporin A with or without G-CSF in adults; a multicenter randomized study in Japan Blood 2007; 110: 1756-1761.

Tichelli A, Socié G, Marsh J, et al, for the European Group for Blood and Marrow Transplantation Severe Aplastic Anaemia Working Party. Outcome of pregnancy and disease course among women with aplastic anemia treated with immunosuppression. Ann Intern Med. 2002; 137: 164-172. http://dx.doi.org/10.7326/0003-4819-137-3-200208060-00008

Bacigalupo A, Brand R, Oneto R, et al. Treatment of acquired severe aplastic anemia: bone marrow transplantation compared with immunosuppressive therapy-The European Group for Blood and Marrow Transplantation experience. Semin Hematol 2000; 37: 69-80. http://dx.doi.org/10.1016/S0037-1963(00)90031-3

Locasciulli A, Oneto R, Bacigalupo A, et al.; Severe Aplastic Anemia Working Party of the European Blood and Marrow Transplant Group. Outcome of patients with acquired aplastic anemia given first line bone marrow transplantation or immunosuppressive treatment in the last decade: a report from the European Group for Blood and Marrow Transplantation (EBMT) Haematologica 2007; 92: 11-18. http://dx.doi.org/10.3324/haematol.10075

Downloads

Published

2016-08-12

Issue

Vol. 3 No. 2 (2016)

Section

Articles

License

Policy for Journals/Articles with Open Access

Authors who publish with this journal agree to the following terms:
    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work

Policy for Journals / Manuscript with Paid Access

Authors who publish with this journal agree to the following terms:
    1. Publisher retain copyright .

  1. Authors are permitted and encouraged to post links to their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work .