Vitamin B12 and/or Folate Deficiency is a Cause of Macro Thrombocytopenia

Authors

  • Anupama Jaggia Bedford NHS Hospital Trust, Bedford MK42 9DU, UK
  • Adrian Northern Bedford NHS Hospital Trust, Bedford MK42 9DU, UK

DOI:

https://doi.org/10.15379/2408-9877.2015.02.02.04

Keywords:

Vitamin B12 deficiency, Large platelets, Isolated thrombocytopenia, Macro thrombocytopenia.

Abstract

This retrospective study reveals that it is likely that vitamin B12 and / or folate deficiency is an important cause for isolated thrombocytopenia with larger than normal sized platelets. Data collection and interpretation from the laboratory has revealed this and as this can have further therapeutic utility, more studies on the subject are indicated. Hypothyroidism may also be another cause for the findings.

References

Heiligers-Duckers C, Werner PT, van Drunen ME. Reticulocytes in the diagnosis of anaemia. Ned Tijdschr Geneeskd. 2013; 157: A6313.

Guilland JC, Aimone-Gastin I. Vitamin B9. Rev Prat 2013 Oct; 63: 1079, 1081-4.

Noël N, Maigné G, Tertian G, Anguel N, Monnet X, Michot JM, Goujard C, Lambotte O. Hemolysis and schistocytosis in the emergency department: consider pseudothrombotic microangiopathy related to vitamin B12 deficiency. QJM 2013 Nov; 106: 1017-22. http://dx.doi.org/10.1093/qjmed/hct142

Nafil H, Tazi I, Sifessalam M, Bouchtia M, Mahmal L. Clinical, biological and therapeutic profile of anemia by vitamin B12 deficiency in the department of hematology of Marrakech (Morocco).Bull Soc Pathol Exot. 2013 May; 106: 83-8. http://dx.doi.org/10.1007/s13149-013-0282-4

Okur M, Ozkan A, Gunes C, Kaya M, Kocabay K. Case of isolated thrombocytopenia due to cobalamin deficiency. Int J Hematol 2011 Nov; 94: 488-90. http://dx.doi.org/10.1007/s12185-011-0946-0

Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol. 1990; 34: 99-107. http://dx.doi.org/10.1002/ajh.2830340205

Stabler SP. Screening the older population for cobalamin (vitamin B12) deficiency. J Am Geriatr Soc. 1995; 43: 1290-7. http://dx.doi.org/10.1111/j.1532-5415.1995.tb07408.x

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Published

2015-07-30

Issue

Vol. 2 No. 2 (2015)

Section

Articles

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